Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1GV7K)

Drug Name

Pomolic acid Drug Info

Synonyms

Pomolic acid; 13849-91-7; UNII-60HAB1ZK1T; 60HAB1ZK1T; CHEMBL486986; CHEBI:66772; (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; AC1L8K6D; SCHEMBL1049001; Urs-12-en-28-oic acid, 3,19-dihydroxy-, (3beta)-; MolPort-028-754-128; ZINC6003698; BDBM50241553; NSC670661; AKOS032948112; NSC-670661; NCI60_024874; W2587; Urs-12-en-28-oic acid, 3,19-dihydroxy-, (3.beta.)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 382831
ChEBI ID: CHEBI:66772
CAS Number: CAS 13849-91-7
TTD Drug ID: DM1GV7K

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[2]
TRYPAN BLUE	DM4NTMO	Ophthalmic surgery injury	PK97	Approved	[3]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[4]
ISIS 113715	DMUPD4G	Type-2 diabetes	5A11	Phase 2	[5]
ISIS-PTP1Brx	DMJGVXT	Type-2 diabetes	5A11	Phase 2	[6]
ERTIPROTAFIB	DMJXEV7	Type-2 diabetes	5A11	Terminated	[7]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[8]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[8]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[8]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PTPN1 messenger RNA (PTPN1 mRNA)	TTELIN2	PTN1_HUMAN	Inhibitor	[1]

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References

1	Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8.
2	Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
3	Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.
4	Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
5	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
6	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
7	2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60.
8	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.