Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1I25F)

Drug Name

8-Pyridin-4-yl-9H-purine-2,6-diamine Drug Info

Synonyms

CHEMBL317618; 8-Pyridin-4-yl-9H-purine-2,6-diamine; 9H-Purine-2,6-diamine, 8-(4-pyridinyl)-; AC1L9X4Y; BDBM50059928; 2,6-Diamino-8-(4'-pyridinyl)purine; 8-pyridin-4-yl-7H-purine-2,6-diamine; 8-(4-pyridyl)-9H-purine-2,6-diamine; 194613-23-5

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 457739
TTD Drug ID: DM1I25F

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Polypeptide deformylase (PDF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[2]
Meprobamate	DMHM93Y	Anxiety		Approved	[3]
Pralatrexate	DMAO80I	Breast cancer	2C60-2C65	Approved	[4]
Ustekinumab	DMHTYK3	Plaque psoriasis	EA90.0	Approved	[5]
Trimetrexate	DMDEA85	Toxoplasmosis	1F57	Approved	[6]
MCB-3837	DM0R4Z5	Malaria	1F40-1F45	Approved	[3]
Chlorproguanil	DM1IFGT	Malaria	1F40-1F45	Approved	[3]
LY333531	DMGMC8H	Solid tumour/cancer	2A00-2F9Z	Phase 2	[7]
Metoprine	DM5GQD7	Advanced cancer	2A00-2F9Z	Phase 2	[8]
Aminopterin	DMQ9RBV	leukaemia	2A60-2B33	Withdrawn from market	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polypeptide deformylase (PDF)	TT9SL3Q	DEFM_HUMAN	Inhibitor	[1]

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References

1	Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneum... J Med Chem. 1997 Sep 12;40(19):3032-9.
2	Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6.
3	The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
4	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
5	Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase. Antimicrob Agents Chemother. 2002 Nov;46(11):3362-9.
6	Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase. Antimicrob Agents Chemother. 2000 Nov;44(11):3092-6.
7	Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J Mol Biol. 2000 Jan 14;295(2):307-23.
8	Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34.
9	Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer. 2003 Feb 20;103(5):587-99.