General Information of Drug (ID: DM1IBRT)

Drug Name
OPN-305 Drug Info
Synonyms OPN-301; TLR-specific mAbs (inflammatory diseases), Opsona; Toll-like receptor specific monoclonal antibodies (inflammatory diseases), Opsona
Indication
Disease Entry ICD 11 Status REF
Myelodysplastic syndrome 2A37 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM1IBRT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Toll-like receptor 2 (TLR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cadi-05 DMPTCYB Prostate cancer 2C82.0 Phase 3 [3]
MCS-18 DMX4U0B Autoimmune diabetes 5A10 Phase 2 [4]
MALP-2S DMBZ68C Pancreatic cancer 2C10 Phase 1/2 [5]
Lipoteichoic acid DMEMRW0 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [6]
OM-174 DM2THBX Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
F-50040 DMMG6W5 Melanoma 2C30 Discontinued in Phase 1 [8]
S-(Dimethylarsenic)Cysteine DMSCHL0 Discovery agent N.A. Investigative [9]
CBLB-612 DMCFR8U Radiation syndrome NF00 Investigative [10]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 2 (TLR2) TTY7ZHS TLR2_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT01794663) Placebo-Controlled Study to Evaluate the Safety and Efficacy of OPN-305 in Preventing Delayed Renal Graft Function. U.S. National Institutes of Health.
2 Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs. Circ Cardiovasc Interv. 2012 Apr;5(2):279-87.
3 Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.
4 The novel arthritis-drug substance MCS-18 attenuates the antibody production in vivo. Acta Microbiol Immunol Hung. 2008 Mar;55(1):15-31.
5 Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2. Microbes Infect. 2011 Apr;13(4):350-8.
6 Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccha... J Biol Chem. 2003 May 2;278(18):15587-94.
7 Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors. BMC Cancer. 2013 Apr 2;13:172.
8 Stability and CTL-activity of P40/ELA melanoma vaccine candidate. Biologicals. 2001 Sep-Dec;29(3-4):293-8.
9 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
10 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1752).