Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1ITDN)

Drug Name

NsG-0202 Drug Info

Synonyms

ECB-AD; ECT-AD; ECT-NGF; ECT (Alzheimers Disease), NsGene; Encapsulated cell technology (Alzheimers Disease), NsGene; Encapsulated ARPE-19 cells (Alzheimers disease), NsGene

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DM1ITDN

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Nerve growth factor (NGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tanezumab	DMJKWMA	Cancer related pain	MG30	Phase 3	[3]
Fasinumab	DM5PRLA	Chronic low back pain	MG30.02	Phase 3	[3]
SAR164877	DMOJLCV	Pain	MG30-MG3Z	Phase 2/3	[4]
CERE-110	DMNW5I9	Alzheimer disease	8A20	Phase 2	[5]
CXB-909	DMUGMFN	Neurodegenerative disorder	8A20-8A23	Phase 1/2	[2]
ABT-110	DM1F50I	Chronic pain	MG30	Phase 1	[4]
MEDI-578	DMPW21Z	Pain	MG30-MG3Z	Phase 1	[4]
Nerve growth factor	DMHYQ8K	Alzheimer disease	8A20	Terminated	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nerve growth factor (NGF)	TTDN3LF	NGF_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01163825) Encapsulated Cell Biodelivery of Nerve Growth Factor to Alzheimer Disease Patients. U.S. National Institutes of Health.
2	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Fate of novel painkiller mAbs hangs in balance.Nat Biotechnol.2011 Mar;29(3):173-4.
5	CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease. Curr Opin Mol Ther. 2010 Apr;12(2):240-7.
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.