Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1JCW8)

Drug Name
Xaliproden Drug Info
Synonyms
Xaliproden (USAN); 1,2,3,6-tetrahydro-1-(2-(2-naphthalenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)-pyridine; 1,2,3,6-tetrahydro-1-(2-(2-naphthyl)ethyl)-4-(alpha,alpha,alpha-trifluoro-m-tolyl)pyridine; 1-(2-(2-Naphthyl)ethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine; 1-(2-naphthalen-2-ylethyl)-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine; 1-[2-(2-naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine
Indication
Disease Entry ICD 11 Status REF
Juvenile idiopathic arthritis FA24 Phase 3 [1]
Plaque psoriasis EA90.0 Phase 3 [1]
Alzheimer disease 8A20 Discontinued in Phase 3 [2]
Lateral sclerosis 8B61 Discontinued in Phase 3 [2]
Peripheral sensory neuropathies LD27.3 Discontinued in Phase 3 [2]
Cross-matching ID
PubChem CID
128919
ChEBI ID
CHEMBL1512580
CAS Number
CAS 135354-02-8
TTD Drug ID
DM1JCW8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting 5-HT 1A receptor (HTR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [4]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [5]
OPC-34712 DMHG57U Major depressive disorder 6A70.3 Approved [6]
Vilazodone DM4LECQ Major depressive disorder 6A70.3 Approved [7]
Flibanserin DM70DTN Depression 6A70-6A7Z Approved [8]
Gepirone DMGX5Q0 Major depressive disorder 6A70.3 Approved [9]
TERTATOLOL DM2L3D5 Hypertension BA00-BA04 Approved [10]
Urapidil DMD59GI Hypertension BA00-BA04 Approved [11]
Treximet DMU54QB Migraine 8A80 Approved [12]
CM-2395 DMASPWR Schizophrenia 6A20 Phase 3 [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Antagonist [3]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001601)
3 Pharma & Vaccines. Product Development Pipeline. April 29 2009.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handb Exp Pharmacol. 2005;(169):181-204.
6 Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.Pharmacol Biochem Behav.2014 Sep;124:245-9.
7 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
8 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
9 Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
10 Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993).
11 Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55.
12 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
13 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)