General Information of Drug (ID: DM1K2A4)

Drug Name
N*6*-Cyclohexyl-N*2*-ethyl-9H-purine-2,6-diamine Drug Info
Synonyms CHEMBL191551; N*6*-Cyclohexyl-N*2*-ethyl-9H-purine-2,6-diamine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11334464
TTD Drug ID
DM1K2A4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
IB-MECA DM9G5XD Psoriasis vulgaris EA90 Phase 3 [2]
Tonapofylline DMBH316 Acute and chronic heart failure BD1Z Phase 2 [3]
NITD609 DMQHBSX Malaria 1F40-1F45 Phase 2 [4]
CF102 DMP56WJ Hepatocellular carcinoma 2C12.02 Phase 2 [5]
SCH-442416 DMQ2K1V N. A. N. A. Phase 1 [6]
AST-004 DM5WMG7 Stroke 8B20 Phase 1 [7]
BEMESETRON DMSPJX9 N. A. N. A. Discontinued in Phase 3 [8]
BAY 60-6583 DMTEJV1 Myocardial ischemia BA6Z Preclinical [9]
CF602 DM0ULO2 Inflammation 1A00-CA43.1 Preclinical [5]
CF502 DMQSJ20 Inflammation 1A00-CA43.1 Preclinical [5]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [10]
Rolofylline DMSZPR3 Heart failure BD10-BD13 Phase 3 [11]
Tonapofylline DMBH316 Acute and chronic heart failure BD1Z Phase 2 [3]
AMP-579 DMJ4GPR Hyperlipidaemia 5C80 Phase 2 [12]
SELODENOSON DMQM3IX Cardiac arrhythmias BC9Z Phase 2 [13]
Apaxifylline DMQMV9F Cognitive impairment 6D71 Phase 2 [14]
SLV320 DM867BJ Heart failure BD10-BD13 Phase 2 [15]
DTI-0009 DMV84OK Atrial fibrillation BC81.3 Phase 2 [13]
Capadenoson DMYWO62 Atrial fibrillation BC81.3 Phase 2 [16]
BAY 1067197 DM4JGNH Heart failure BD10-BD13 Phase 2 [17]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenosine A1 receptor (ADORA1) TTK25J1 AA1R_HUMAN Inhibitor [1]
Adenosine A3 receptor (ADORA3) TTJFY5U AA3R_HUMAN Inhibitor [1]

References

1 Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8.
2 A role for central A3-adenosine receptors. Mediation of behavioral depressant effects. FEBS Lett. 1993 Dec 20;336(1):57-60.
3 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203.
4 Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329(5996):1175-80.
5 2011 Pipeline of Can-Fite BioPharm.
6 Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5690-4.
7 Adenosine A1R/A3R (Adenosine A1 and A3 Receptor) Agonist AST-004 Reduces Brain Infarction in a Nonhuman Primate Model of Stroke. Stroke. 2022 Jan;53(1):238-248.
8 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96.
9 Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion. J Mol Cell Cardiol. 2007 Sep;43(3):262-71.
10 Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72.
11 Association between the PDE4D gene and ischaemic stroke in the Chinese Han population. Clin Sci (Lond). 2009 Aug 17;117(7):265-72.
12 Adenosine A1/A2a receptor agonist AMP-579 induces acute and delayed preconditioning against in vivo myocardial stunning. Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2746-53.
13 Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim Biophys Acta. 2011 May;1808(5):1290-308.
14 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004779)
15 Role of matrix metalloproteinases and their tissue inhibitors as potential biomarkers of left ventricular remodelling in the athlete's heart. Clin Sci (Lond). 2009 Jul 16;117(4):157-64.
16 A1 adenosine receptor agonists and their potential therapeutic applications. Expert Opin Investig Drugs. 2008 Dec;17(12):1901-10.
17 Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist. Current Issue vol. 111 no. 12 Celine Valant, 4614-4619.