Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1LDIP)

Drug Name

EcoNail Drug Info

Synonyms

Econazole/SEPA

Indication

Disease Entry	ICD 11	Status	REF
Fungal infection	1F29-1F2F	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Candida Cytochrome P450 51 (Candi ERG11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[3]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[3]
Posaconazole	DMUL5EW	Aspergillosis	1F20	Approved	[4]
Ketoconazole	DMPZI3Q	Blastomycosis	1F22	Approved	[5]
Miconazole	DMPMYE8	Cutaneous candidiasis	1F23.14	Approved	[3]
Oxiconazole	DME7KRM	Tinea corporis	1F28.Y	Approved	[6]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[3]
Terconazole	DMJ13KI	Candidiasis	1F23	Approved	[7]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[8]
Tioconazole	DMNYPGS	Onychomycosis	EE12.1	Approved	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Candida Cytochrome P450 51 (Candi ERG11)	TTTSOUD	CP51_CANAL	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT00385502) A Trial of the Safety and Efficacy of EcoNail in the Treatment of Fungus Infections of the Great Toenail. U.S. National Institutes of Health.
2	Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	A new, broad-spectrum azole antifungal: posaconazole--mechanisms of action and resistance, spectrum of activity. Mycoses. 2006;49 Suppl 1:2-6.
5	Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302.
6	Antifungal agents: mechanisms of action. Trends Microbiol. 2003 Jun;11(6):272-9.
7	Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1193-9.
8	Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7.
9	Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):261-6.