General Information of Drug (ID: DM1M57I)

Drug Name
MK-2578 Drug Info
Indication
Disease Entry ICD 11 Status REF
Anemia 3A00-3A9Z Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM1M57I

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug(s) Targeting Erythropoietin (EPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LKA651 DMCFGP3 Diabetic macular edema 9B71.02 Phase 2 [3]
Erythropoietin-transfected autologous cell therapy DMNZ6VA Anemia 3A00-3A9Z Phase 1/2 [4]
Long-acting erythropoietin conjugate DM9OA35 Anemia 3A00-3A9Z Phase 1 [5]
GC-1113 DMK96CE Anemia 3A00-3A9Z Phase 1 [6]
FC EPO DMEX12T Anemia 3A00-3A9Z Discontinued in Phase 1 [7]
GLY-515n DM0IKB4 Cerebrovascular ischaemia 8B1Z Terminated [8]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Erythropoietin (EPO) TTQG4NR EPO_HUMAN Agonist [2]

References

1 ClinicalTrials.gov (NCT00968617) A Study of MK2578 in Patients With Chronic Kidney Disease Who Are Not on Dialysis (2578-002). U.S. National Institutes of Health.
2 Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636.
3 Clinical pipeline report, company report or official report of Novartis.
4 Mesenchymal stromal cells engineered to express erythropoietin induce anti-erythropoietin antibodies and anemia in allorecipients. Mol Ther. 2009 Feb;17(2):369-72.
5 Company report (Pharmexcil)
6 A long-acting erythropoietin fused with noncytolytic human Fc for the treatment of anemia. Arch Pharm Res. 2012 May;35(5):757-9.
7 Detection of EPO-Fc fusion protein in human blood: screening and confirmation protocols for sports drug testing. Drug Test Anal. 2012 Nov;4(11):818-29.
8 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027536)