Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1NXDA)

Drug Name

[125I]CGP42112 Drug Info

Synonyms

UXGNARZDONUMMK-LRMQDCNJSA-N; Cgp-42112A; Cgp 42112; 127060-75-7; CGP 42112A; CGP-42112; Cgp 42112B; CGP42112A; Nicotinic acid-tyr-(N(sigma)-benzyloxycarbonyl-arg)lys-his-pro-ile-OH; Nicotinic acid-tyrosyl-(N(sigma)-benzyloxycarbonyl-arginyl)lysyl-histidyl-prolyl-isoleucine-OH; L-Isoleucine, N-(1-(N-(N6-(N2-((phenylmethoxy)carbonyl)-L-arginyl)-N2-(N-(3-pyridinylcarbonyl)-L-tyrosyl)-L-lysyl)-L-histidyl)-L-prolyl)-; CGP42112; Cgp 42112B; [125I]-CGP42112

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 123794
ChEBI ID: CHEBI:147302
CAS Number: CAS 127060-75-7
TTD Drug ID: DM1NXDA

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Discontinued Drug(s)

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Drug(s) Targeting Angiotensin II receptor type-2 (AGTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ANGIOTENSIN II	DMLWQ27	Increase blood pressure	BA04	Approved	[3]
SARALASIN	DMKS1DV	Hypertension	BA00-BA04	Approved	[4]
EMA-401	DMYOUB6	Peripheral neuropathy	8C0Z	Phase 2	[5]
MP-157	DM5VXWO	Hypertension	BA00-BA04	Phase 1	[6]
PMID25416646-Compound-Figure5-E	DMYO7VH	N. A.	N. A.	Patented	[7]
Phenylpyridine derivative 3	DMDT5JI	N. A.	N. A.	Patented	[7]
1-(biphenyl-4-yl-methyl)-1H-imidazole derivative 1	DMGYZQ2	N. A.	N. A.	Patented	[7]
Fonsartan	DM15LAP	Hypertension	BA00-BA04	Discontinued in Phase 2	[8]
L-158282	DMKSEIY	N. A.	N. A.	Discontinued in Phase 2	[9]
TAK-591	DM25DB4	Hypertension	BA00-BA04	Discontinued in Phase 1	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin II receptor type-2 (AGTR2)	TTQVOEI	AGTR2_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 594).
2	Radioiodinated CGP 42112A: a novel high affinity and highly selective ligand for the characterization of angiotensin AT2 receptors. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1365-71.
3	The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists, Bioorg. Med. Chem. Lett. 3(5):895-898 (1993).
4	cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.
5	Clinical pipeline report, company report or official report of Spinifex.
6	As drug target reemerges, the question is to block or stimulate it. Nature Medicine. Spoonful of Medicine. 05 Feb 2014. Cassandra Willyard
7	PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91.
8	Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J Hypertens. 1998 Dec;16(12 Pt 2):2039-43.
9	Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors, Bioorg. Med. Chem. Lett. 4(1):189-194 (1994).
10	Clinical pipeline report, company report or official report of Takeda (2009).