Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2AIE9)

Drug Name

ABC-7 Drug Info

Synonyms

RON tyrosine kinase targeted antibody (solid tumor), XOMA; Recepteur d'origine nantais tyrosine kinase targeted antibody (solid tumor), XOMA

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Macrophage-stimulating protein receptor (RON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MK-2461	DM21WBH	Alzheimer disease	8A20	Phase 1/2	[2]
Anti-RON receptor mabs	DMXACM2	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Macrophage-stimulating protein receptor (RON)	TTBQ3OC	RON_HUMAN	Not Available	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1816).
2	MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33.