Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2CK7B)

Drug Name

HESPERADIN Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Aurora B messenger RNA (AURKB mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PHA-739358	DMGYBZI	Prostate cancer	2C82.0	Phase 2	[3]
Indirubin-3'-monoxime	DMLRQH0	Discovery agent	N.A.	Investigative	[4]
SU 6656	DMF1P6W	Discovery agent	N.A.	Investigative	[5]
6-bromoindirubin-3-oxime	DM12WYV	Discovery agent	N.A.	Investigative	[4]
7-fluoroindirubin-3-oxime	DMQD34N	Discovery agent	N.A.	Investigative	[4]
PMID21742770C1	DME3JMH	Discovery agent	N.A.	Investigative	[6]
Indirubin-3-acetoxime	DM3UR1E	Discovery agent	N.A.	Investigative	[4]
CGP-57380	DMFPOUC	Discovery agent	N.A.	Investigative	[5]
PMID20855207C25	DMNEB6J	Discovery agent	N.A.	Investigative	[7]
Indirubin-3-methoxime	DMZ5ODC	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aurora B messenger RNA (AURKB mRNA)	TT9RTBL	AURKB_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8354).
2	Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J Med Chem. 2006 Feb 9;49(3):955-70.
3	Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. J Med Chem. 2005 Apr 21;48(8):3080-4.
4	An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37.
5	The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
6	A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038.
7	Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43.