Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2K6I8)

Drug Name

Ryanodine Drug Info

Synonyms

ryanodine; Ryanodin; 15662-33-6; Ryania; Ryanodol, 3-(1H-pyrrole-2-carboxylate); Ryanadol; (3S,4R,4aR,6S,6aR,7S,8R,8aS,8bR,9S,9aS)-4,6,7,8a,8b,9a-hexahydroxy-7-isopropyl-3,6a,9-trimethyldodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylate; (3S,4R,4aR,6S,6aR,7S,8R,8aS,8bR,9S,9aS)-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(propan-2-yl)dodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylate; 3-(1H-pyrrole-2-carboxylate; Ryanodine High Purity

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11317883
ChEBI ID: CHEBI:8925
CAS Number: CAS 15662-33-6
TTD Drug ID: DM2K6I8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Ryanodine receptor 1 (RYR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARM036	DMNGQM0	Heart failure	BD10-BD13	Discontinued in Phase 2	[3]
CDP-1050	DM5BG4P	Heart failure	BD10-BD13	Discontinued in Phase 1	[3]
Benzyloxycarbonyl-glycylryanodine	DMLJMOD	Discovery agent	N.A.	Investigative	[4]
Ruthenium red	DMOHTC6	Discovery agent	N.A.	Investigative	[5]
(O10eq)-beta-alanyl-anhydro-ryanodine	DMRSZGB	Discovery agent	N.A.	Investigative	[4]
GLYCYLRYANODINE	DMTOCXZ	Discovery agent	N.A.	Investigative	[4]
N-methyl ryanodine-succinamidate	DMXGY4F	Discovery agent	N.A.	Investigative	[4]
Di-Benzyloxycarbonyl-guanidino acetylryanodine	DMAYSGI	Discovery agent	N.A.	Investigative	[4]
(O10eq)-beta-guanidinopropionylryanodine	DMSV8XM	Discovery agent	N.A.	Investigative	[4]
(O10eq)-guanidino acetylryanodine	DM97W5T	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ryanodine receptor 1 (RYR1)	TTU5CIX	RYR1_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4303).
2	The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca(2+) signaling of airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L347-61.
3	The Ryanodine Receptor Stabilizer S44121 / Arm036 Improves Peripheral and Respiratory Muscle Function in a Mouse Model of Heart Failure. Circulation. 2014; 130: A13726.
4	Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23.
5	Role of ryanodine receptor channels in Ca2+ oscillations of porcine tracheal smooth muscle. Am J Physiol. 1997 Apr;272(4 Pt 1):L659-64.