Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2L9CO)

Drug Name

Ezatiostat Drug Info

Synonyms

Telintra (TN)

Indication

Disease Entry	ICD 11	Status	REF
Myelodysplastic syndrome	2A37	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Canfosfamide	DM4FHQR	Solid tumour/cancer	2A00-2F9Z	Phase 3	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutathione S-transferase P (GSTP1)	TT40K12	GSTP1_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01422486) Phase 2 Study of Telintra in Deletion 5q Myelodysplastic Syndrome. U.S. National Institutes of Health.
2	National Cancer Institute Drug Dictionary (drug id 485244).
3	Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA). Biochemistry. 2013 Nov 12;52(45):8069-78.