Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2VJ1U)

Drug Name
PF-06730512 Drug Info
Indication
Disease Entry ICD 11 Status REF
Focal segmental glomerulosclerosis MF8Y Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM2VJ1U

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Slit homolog 2 protein (SLIT2) TTDWK85 SLIT2_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT03448692) A PHASE 2, 24-WEEK, ADAPTIVE, OPEN LABEL, SEQUENTIAL COHORT TRIAL TO EVALUATE THE EFFICACY, SAFETY, TOLERABILITY AND PHARMACOKINETICS OF PF-06730512 FOLLOWING MULTIPLE DOSES IN ADULT SUBJECTS WITH FOCAL SEGMENTAL GLOMERULOSCLEROSIS (FSGS). U.S.National Institutes of Health.
2 PODO: Trial Design: Phase 2 Study of PF-06730512 in Focal Segmental Glomerulosclerosis. Kidney Int Rep. 2021 Apr 3;6(6):1629-1633.