Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2Y0AI)

Drug Name

Diminazene Drug Info

Synonyms

DIMINAZENE; 536-71-0; berenil; Diminazenum; Diminazeno; Diminazine; Azidin; Pirocide; Diminazene [INN:BAN]; Diminazenum [INN-Latin]; Diminazeno [INN-Spanish]; UNII-Y5G36EEA5Z; 4,4'-(Diazoamino)benzamidine; CHEBI:81724; 4,4'-(1-Triazene-1,3-diyl)bis-benzenecarboximidamide; Benzenecarboximidamide, 4,4'-(1-triazene-1,3-diyl)bis-; EINECS 208-644-6; Y5G36EEA5Z; C14H15N7; Bevenil; 1,3-TRIS-(4'AMIDINOPHENYL)TRIAZINE; 4,4'-(Triaz-1-ene-1,3-diyl)dibenzimidamide; 4,4'-(1-Triazene-1,3-diyl)bisbenzenecarboximidamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2354
ChEBI ID: CHEBI:81724
CAS Number: CAS 536-71-0
TTD Drug ID: DM2Y0AI

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[3]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[4]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[4]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[4]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[4]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[4]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[4]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[4]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Diamine oxidase (AOC1)	TTM3B5R	AOC1_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Gene/Protein Processing	[2]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Prediction of off-target effects on angiotensin-converting enzyme 2. J Biomol Screen. 2011 Sep;16(8):878-85. doi: 10.1177/1087057111413919. Epub 2011 Aug 22.
3	Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women. Clin Pharmacol Ther. 2007 Aug;82(2):187-96. doi: 10.1038/sj.clpt.6100214. Epub 2007 May 2.
4	Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.