General Information of Drug (ID: DM34W56)

Drug Name
AZD-7806 Drug Info
Synonyms AZD 7806; AZD7806
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9939892
CAS Number
CAS 439087-18-0
TTD Drug ID
DM34W56

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Odevixibat DMYN391 Pruritus EC90 Approved [2]
Maralixibat DMJCF1O Pruritus EC90 Approved [2]
A-3309 DM4OHMP Lipid metabolism disorder 5C52.Z Phase 3 [1]
LUM001 DMQZXDW Primary biliary cholangitis DB96.1 Phase 2 [3]
S-8921 DMRZA6G Hyperlipidaemia 5C80 Phase 2 [4]
264W94 DMBOL4K Hyperlipidaemia 5C80 Phase 2 [5]
GSK2330672 DM4BTH8 Pruritus EC90 Phase 2 [6]
Taurocholic Acid DM2LZ8F Type-2 diabetes 5A11 Phase 1/2 [7]
1614235 + 2330672 DMD751X Type-2 diabetes 5A11 Phase 1 [8]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ileal sodium/bile acid cotransporter (SLC10A2) TTPI1M5 NTCP2_HUMAN Modulator [1]

References

1 Elobixibat for the treatment of constipation. Expert Opin Investig Drugs. 2013 Feb;22(2):277-84.
2 Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders. Hepatol Int. 2020 Sep;14(5):677-689.
3 Current research on the treatment of primary sclerosing cholangitis. Intractable Rare Dis Res. 2015 Feb; 4(1): 1-6.
4 Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1304-11.
5 Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes. Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E68-76.
6 Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem. 2013 Jun 27;56(12):5094-114.
7 Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1 Pt 1):G157-69.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 960).