Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3TW9V)

Drug Name

(S)-3-hydroxy-3-methylglutaryl-CoA Drug Info

Synonyms

hydroxymethylglutaryl-CoA; 3-Hydroxy-3-methylglutaryl-CoA ; 3-hydroxy-3-methylglutaryl-coenzyme A; HMG-CoA

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Hydroxymethylglutaryl-CoA synthase 1 (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-659,699	DMDF0KZ	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hydroxymethylglutaryl-CoA synthase 1 (HMGCS1)	TTQF4TK	HMCS1_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3040).
2	A visible wavelength spectrophotometric assay suitable for high-throughput screening of 3-hydroxy-3-methylglutaryl-CoA synthase. Anal Biochem. 2010 Jan 1;396(1):96-102.
3	Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by beta-lactone inhibitors and binding of these inhibitors to the enzyme. Biochem J. 1993 Feb 1;289 ( Pt 3):889-95.