General Information of Drug (ID: DM4FZWP)

Drug Name
UK-279,276 Drug Info
Indication
Disease Entry ICD 11 Status REF
Stroke 8B20 Discontinued in Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM4FZWP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Integrin beta-2 (ITGB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RP-L201 DMKVMWO Leukocyte adhesion deficiency type 1 4A00.0Y Phase 1/2 [3]
BMS-587101 DMS2IC9 Psoriasis vulgaris EA90 Discontinued in Phase 2 [4]
MLN-2201 DMQA5JW Cerebrovascular ischaemia 8B1Z Discontinued in Phase 1 [5]
A-286982 DM98VFW Discovery agent N.A. Investigative [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Integrin beta-2 (ITGB2) TTIJWR7 ITB2_HUMAN Antagonist [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003726)
2 Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin Emerg Drugs. 2007 Mar;12(1):97-112.
3 Clinical pipeline report, company report or official report of Rocket Pharmaceuticals.
4 Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thioph... J Med Chem. 2006 Nov 30;49(24):6946-9.
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010178)
6 Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism o... J Med Chem. 2001 Apr 12;44(8):1202-10.