Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4NBUH)

Drug Name

1-D-glucopyranosyl cytosine Drug Info

Synonyms

1-D-glucopyranosyl cytosine; CHEMBL1096136; 4-Amino-1-Beta-D-Glucopyranosylpyrimidin-2(1h)-One; 1-D-glucopyranosyl-cytosine; SCHEMBL7520145; 1-beta-D-Glucopyranosylcytosine; BDBM50316588

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 21678292
TTD Drug ID: DM4NBUH

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Glycogen phosphorylase muscle form (GP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[2]
JTT-651	DMGP42Q	Type-2 diabetes	5A11	Discontinued in Phase 1	[3]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[4]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[4]
Indirubin-5-sulfonate	DM08VHZ	Discovery agent	N.A.	Investigative	[4]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[4]
Alpha-D-Glucose-6-Phosphate	DMR0EVN	Discovery agent	N.A.	Investigative	[4]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[4]
OLEANOLIC_ACID	DMWDMJ3	Discovery agent	N.A.	Investigative	[5]
Oleanonic acid	DMYPJC3	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[1]

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References

1	1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modellin... Bioorg Med Chem. 2010 May 15;18(10):3413-25.
2	Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8.
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026877)
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54.