Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4OQWZ)

Drug Name

Malate Like Intermediate Drug Info

Synonyms

MALATE LIKE INTERMEDIATE; AC1NRDBV; DB03343; (Z,2R)-2,4-dihydroxy-4-oxidobut-3-enoate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Bacterial Fumarate reductase flavoprotein (Bact frdA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thiabendazole	DM7YCK3	Ascariasis	1F62	Approved	[2]
Oxantel pamoate	DMZ30JT	Trichuris trichiura infection	1F6G	Approved	[2]
Morantel tartrate	DM560Y3	Mature gastrointestinal nematode infection	1F6Y	Approved	[2]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[3]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[4]
Fumarate	DM9VLS2	Discovery agent	N.A.	Investigative	[3]
2,3-DIMETHYL-1,4-NAPHTHOQUINONE	DMGXVBA	Discovery agent	N.A.	Investigative	[4]
Citraconic acid	DMCIM9A	Discovery agent	N.A.	Investigative	[1]
2-[1-(4-CHLORO-PHENYL)-ETHYL]-4,6-DINITRO-PHENOL	DMUZDSC	Discovery agent	N.A.	Investigative	[4]
2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE	DMJ3ATL	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Fumarate reductase flavoprotein (Bact frdA)	TTHDSE2	FRDA_HELPY	Inhibitor	[1]

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References

1	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
2	Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach. Microb Pathog. 2000 Nov;29(5):279-87.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.