Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4Q5TX)

Drug Name

6-fluoro-5-phenylpyrimidine-2,4(1H,3H)-dione Drug Info

Synonyms

CHEMBL395907; BDBM20075; 6-Fluoro-5-phenylpyrimidine-2,4(1H,3H)-dione, 21

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Thymidine phosphorylase (TYMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Uridine	DMQTREB	Depression	6A70-6A7Z	Approved	[2]
5-bromo-6-hydrazinouracil hydrochloride	DMZJE6M	Discovery agent	N.A.	Investigative	[3]
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil	DMEV0GO	Discovery agent	N.A.	Investigative	[4]
6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione	DM90JMN	Discovery agent	N.A.	Investigative	[1]
6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione	DMASFR6	Discovery agent	N.A.	Investigative	[1]
1-(cyclohexyl)methyl-5'-O-tritylinosine	DMS3XUC	Discovery agent	N.A.	Investigative	[5]
1-(cyclopropyl)methyl-5'-O-tritylinosine	DMDU3X7	Discovery agent	N.A.	Investigative	[5]
1-propyl-5'-O-tritylinosine	DM5P01L	Discovery agent	N.A.	Investigative	[5]
1-allyl-5'-O-tritylinosine	DM2J5WH	Discovery agent	N.A.	Investigative	[5]
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione	DMCKODQ	Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thymidine phosphorylase (TYMP)	TTO0IB8	TYPH_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23.
2	Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10.
3	Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7.
4	The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51.
5	5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70.