Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4XETK)

Drug Name

RX108 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Sodium/potassium-transporting ATPase (SPT ATPase)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[2]
Digitoxin	DMWVIGP	Arrhythmia	BC9Z	Approved	[3]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[4]
Rostafuroxin	DMKQXDB	Hypertension	BA00-BA04	Phase 2	[5]
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[6]
Istaroxime	DMWN09H	Cardiac disease	BA00-BE2Z	Discontinued in Phase 2	[7]
Cordil	DMQESM7	Heart arrhythmia	BC65	Terminated	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sodium/potassium-transporting ATPase (SPT ATPase)	TTQ38E9	AT1A1_HUMAN; AT1A2_HUMAN; AT1A3_HUMAN; AT1B1_HUMAN; AT1B2_HUMAN; AT1B3_HUMAN	Inhibitor	[1]

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References

1	ClinicalTrials.gov (NCT03646071) A Study of RX108 in Patients With Locally Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health.
2	Fab antibody fragments: some applications in clinical toxicology. Drug Saf. 2004;27(14):1115-33.
3	Treatment of congestive heart failure--current status of use of digitoxin. Eur J Clin Invest. 2001;31 Suppl 2:10-7.
4	Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81.
5	Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R529-35.
6	First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf- beta and p70s6k, in patients with advanced solid tumors. Invest New Drugs. 2014 Dec;32(6):1204-12.
7	Novel analogues of istaroxime, a potent inhibitor of Na+,K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51(15):4601-8.
8	WO patent application no. 1995,0085,58, Novel deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds.