Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM51FVE)

Drug Name
Zamifenacin Drug Info
Synonyms
Zamifenacin; 127308-82-1; UNII-Y88Q418Y7M; Y88Q418Y7M; Zamifenacin [INN]; 127263-13-2; AC1MJ6I5; DSSTox_RID_82215; DSSTox_CID_27257; DSSTox_GSID_47257; SCHEMBL311829; CHEMBL27507; DTXSID9047257; UK-766542 [As Fumarate]; CHEBI:93417; ZINC3802222; BCP28100; Tox21_300210; AKOS022182209; SB19711; API0007427; UK-76654-2 [AS FUMARATE]; NCGC00247932-01; NCGC00254011-01; AJ-45652; CAS-127308-82-1; BRD-K80451230-051-01-8; (R)-3-(Diphenylmethoxy)-1-(3,4-(methylenedioxy)phenetyl)piperidene
Indication
Disease Entry ICD 11 Status REF
Urinary incontinence MF50.2 Discontinued in Phase 3 [1]
Cross-matching ID
PubChem CID
3086618
ChEBI ID
CHEBI:93417
CAS Number
CAS 127308-82-1
TTD Drug ID
DM51FVE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Muscarinic acetylcholine receptor M3 (CHRM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolterodine DMSHPW8 Overactive bladder GC50.0 Approved [3]
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [4]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [5]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [6]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [7]
Methacholine Chloride DMGS4QH Asthma CA23 Approved [8]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [9]
Solifenacin DMG592Q Overactive bladder GC50.0 Approved [10]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [11]
Cevimeline DMWSMND Sjogren syndrome 4A43.20 Approved [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M3 (CHRM3) TTQ13Z5 ACM3_HUMAN Antagonist [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003650)
2 Drug treatment options for irritable bowel syndrome: managing for success. Drugs Aging. 2001;18(3):201-11.
3 Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther. 2004 Jun;309(3):1148-53.
4 Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
5 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
6 Role of parasympathetic nerves and muscarinic receptors in allergy and asthma.Chem Immunol Allergy.2012;98:48-69.
7 M(1) and M(3) muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor. Pharmacol Res. 2009 May;59(5):300-5.
8 Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am J Respir Cell Mol Biol. 2003 Feb;28(2):257-62.
9 Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol. 2004 Nov;172(5 Pt 1):2059-64.
10 Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout ... Eur J Pharmacol. 2009 Aug 1;615(1-3):201-6.
11 Interaction of neuromuscular blocking drugs with recombinant human m1-m5 muscarinic receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1998 Nov;125(5):1088-94.
12 Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor ... Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G112-G123.