Details of the Drug-Related molecule(s) Interaction Atlas

Indomethacin analog 3 Drug Info

PMID28895472-Compound-22

Cross-matching ID

PubChem CID

71523527

TTD Drug ID

DM53JXE

General Information of Drug (ID: DM53JXE)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Dihydrodiol dehydrogenase type I (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[2]
ASP-9521	DM8V0UL	Prostate cancer	2C82.0	Phase 1/2	[3]
N-(benzimidazole/indole) benzoic acid derivative 2	DMOPUFM	N. A.	N. A.	Patented	[1]
N-(phenylamino)-benzoate derivative 1	DMNIWVG	N. A.	N. A.	Patented	[1]
Indomethacin analog 2	DMKFPJ7	N. A.	N. A.	Patented	[1]
Beta-naphthylacetic acids derivative 1	DM5KTDY	N. A.	N. A.	Patented	[1]
Indomethacin analog 1	DM3E5V6	N. A.	N. A.	Patented	[1]
N-(naphthylamino)-benzoate derivative 1	DM310ES	N. A.	N. A.	Patented	[1]
N-(benzimidazolylcarbonyl)-piperidine derivative 1	DM541QW	N. A.	N. A.	Patented	[1]
Nitrogen/sulfur-substituted estrene derivative 1	DMD7OW0	N. A.	N. A.	Patented	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dihydrodiol dehydrogenase type I (AKR1C3)	TT5ZWB6	AK1C3_HUMAN	Inhibitor; Antagonist; Blocker	[1]

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References

1	Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340.
2	Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51.
3	Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study. Invest New Drugs. 2014 Oct;32(5):995-1004.