General Information of Drug (ID: DM5BV5H)

Drug Name
Daxdilimab Drug Info
Indication
Disease Entry ICD 11 Status REF
Alopecia areata ED70.2 Phase 2 [1]
Dermatomyositis 4A41.0 Phase 2 [2]
Discoid lupus erythematosus EB51.0 Phase 2 [3]
Lupus nephritis 4A40.0Y Phase 2 [4]
Systemic lupus erythematosus 4A40.0 Phase 2 [5]
Cross-matching ID
TTD Drug ID
DM5BV5H

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4) TT7WTBR LIRA4_HUMAN Not Available [6]

References

1 ClinicalTrials.gov (NCT05368103) A Phase 2A, Open Label, Proof of Concept Trial of Daxdilimab for the Treatment of Moderate To Severe Alopecia Areata. U.S.National Institutes of Health.
2 ClinicalTrials.gov (NCT05669014) A Phase 2, Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of Daxdilimab Subcutaneous Injection in Adult Participants With Inadequately Controlled Dermatomyositis or Anti-synthetase Inflammatory Myositis. U.S.National Institutes of Health.
3 ClinicalTrials.gov (NCT05591222) A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial to Investigate the Efficacy and Safety of Daxdilimab Subcutaneous Injection in Reducing Disease Activity in Adult Participants With Moderate-to-Severe Primary Discoid Lupus Erythematosus. U.S.National Institutes of Health.
4 ClinicalTrials.gov (NCT05540665) A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study Evaluating the Efficacy and Safety of Daxdilimab in Adult Participants With Active Proliferative Lupus Nephritis. U.S.National Institutes of Health.
5 ClinicalTrials.gov (NCT05430854) An Open-Label Extension Study To Evaluate The Long- Term Safety And Tolerability Of Daxdilimab (Hzn-7734) In Subjects With Systemic Lupus Erythematosus. U.S.National Institutes of Health.
6 Emerging drugs for the treatment of alopecia areata. Expert Opin Emerg Drugs. 2022 Dec;27(4):379-387.