Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5DWMU)

Drug Name
Rimantadine Drug Info
Synonyms
Remantadine; Riamantadine; Rimant; Rimantadina; Rimantadinum; Enamine_005755; Alpha-Methyladamantanemethylamine; Flumadine (TN); Rimantadina [INN-Spanish]; Rimantadine (INN); Rimantadine [INN:BAN]; Rimantadinum [INN-Latin]; Alpha-Methyl-1-adamantanemethylamine; Rimant & .alpha. IFN; Rimantidine & .alpha.IFN; Tricyclo(3.3.1.1^3,7)decane-1-methanamine, .alpha.-methyl-& IFN.alpha; 1-(1-Adamantyl)ethanamine; 1-(1-Adamantyl)ethylamin; 1-(1-adamantyl)-ethylamine; 1-(1-adamantyl)ethylamine; 1-(adamantan-1-yl)ethan-1-amine; 1-(tricyclo[3.3.1.1~3,7~]dec-1-yl)ethanamine; 1-Adamantan-1-yl-ethylamine; 1-Adamantan-1-ylethylamine; 1-tricyclo[3.3.1.1~3,7~]dec-1-ylethanamine
Indication
Disease Entry ICD 11 Status REF
Influenza A virus infection 1E30 Approved [1]
Influenza virus infection 1E30-1E32 Approved [2]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [3]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
5071
ChEBI ID
CHEBI:94440
CAS Number
CAS 13392-28-4
TTD Drug ID
DM5DWMU
VARIDT Drug ID
DR00832
INTEDE Drug ID
DR2305
ACDINA Drug ID
D00596

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Influenza M2 protein (Influ M)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amantadine DMS3YE9 Influenza A virus infection 1E30 Approved [5]
TCN-032 DM9PVNJ Influenza virus infection 1E30-1E32 Phase 2 [6]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [7]
Spiro[piperidine-2,2-adamantane] DMWU9PV Discovery agent N.A. Investigative [8]
2-(1-adamantyl) piperidine DM05OJD Discovery agent N.A. Investigative [8]
Rimantadine isomer 2 DM3BEF7 Discovery agent N.A. Investigative [8]
2-(1-adamantyl) pyrrolidine DMMSFEU Discovery agent N.A. Investigative [8]
3-(2-adamantyl) pyrrolidine DMS98WA Discovery agent N.A. Investigative [8]
Spiro[pyrrolidine-2,2-adamantane] DMW48JD Discovery agent N.A. Investigative [8]
2-(1-adamantyl)-2-methyl-pyrrolidine DMIGRMV Discovery agent N.A. Investigative [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Influenza M2 protein (Influ M) TTXT3PU M2_I34A1 Inhibitor [4]

References

1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019649.
2 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 076132.
3 In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds. J Clin Virol. 2004 Sep;31(1):69-75. doi: 10.1016/j.jcv.2004.03.003.
4 Antiviral resistance of influenza A (H3N2) strains isolated in northern Greece between 2004 and 2007. Euro Surveill. 2009 Jan 29;14(4). pii: 19104.
5 Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc. 2009 Jun 17;131(23):8066-76.
6 Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses. Proc Natl Acad Sci U S A. 2010 July 13; 107(28): 12658-12663.
7 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
8 Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.