Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5FZH4)

Drug Name

ProstaVac Drug Info

Synonyms

Pox virus vector prostate specific antigen vaccine (benign prostatic hyperplasia/prostatitis); Pox virus vector prostate specific antigen vaccine (benign prostatic hyperplasia/prostatitis), AmVac

Indication

Disease Entry	ICD 11	Status	REF
Prostate hyperplasia	GA90	Phase 3	[1]

Cross-matching ID

TTD Drug ID: DM5FZH4

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Prostate specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PRX-302	DMEH641	Prostate cancer	2C82.0	Phase 3	[3]
Rilimogene galvacirepvec	DMGTCI0	Prostate cancer	2C82.0	Phase 3	[4]
Motexafin lutetium	DM8K5Z6	Artery stenosis	BD52	Phase 3	[5]
ADXS-PSA	DMOPVET	Prostate cancer	2C82.0	Phase 1/2	[2]
MVA-BN Breast	DMFMW5C	Prostate cancer	2C82.0	Phase 1	[6]
PMID23692593C20	DM1T9LJ	Discovery agent	N.A.	Investigative	[7]
VTT-201	DMT967L	Prostate cancer	2C82.0	Investigative	[2]
ProstaRex	DM9GFOM	Prostate cancer	2C82.0	Investigative	[2]
Anti-PSA mabs	DMO21T7	Prostate cancer	2C82.0	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostate specific antigen (KLK3)	TTS78AZ	KLK3_HUMAN	Not Available	[2]

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References

1	Prostvac-VF: a vector-based vaccine targeting PSA in prostate cancer. Expert Opin Investig Drugs. 2009 July; 18(7): 1001-1011.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2373).
3	Phase 1 and 2 studies demonstrate the safety and efficacy of intraprostatic injection of PRX302 for the targeted treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia. Eur Urol. 2011 May;59(5):747-54.
4	Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol. 2010 Mar 1;28(7):1099-105.
5	Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Clin Cancer Res. 2008 Aug 1;14(15):4869-76.
6	Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy. Cancer Res. 2011 Aug 1;71(15):5235-44.
7	Structural optimization, biological evaluation, and application of peptidomimetic prostate specific antigen inhibitors. J Med Chem. 2013 Jun 13;56(11):4224-35.