Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5JZUB)

Drug Name

AMA Drug Info

Synonyms

S-(5'-deoxy-5'-adenosyl)-methylthioethyl-hydroxylamine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Histidine decarboxylase (HDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lixivaptan	DMDN4ZP	Hyponatraemia	5C72	Phase 3	[3]
ALPHA-FMH	DMP9VXQ	Pruritus	EC90	Phase 1	[4]
Brocresine	DM9UF02	Discovery agent	N.A.	Investigative	[5]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histidine decarboxylase (HDC)	TTV9GOF	DCHS_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5134).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1274).
3	Clinical pipeline report, company report or official report of Biofrontera (2009).
4	Alpha-Fluoromethylhistidine. Kinetics of uptake and inhibition of histamine synthesis in basophil (2H3) cell cultures. Mol Pharmacol. 1985 Aug;28(2):191-9.
5	Histamine in brain--its role in regulation of seizure susceptibility. Epilepsy Res. 1991 Nov-Dec;10(2-3):111-8.