Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5S4LX)

Drug Name

Mirvetuximab soravtansine Drug Info

Synonyms

ZOHXWSHGANNQGO-QRVRWUFNSA-N; DB12489

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Folate receptor alpha (FOLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[3]
EC20	DMLA1ER	Ovarian cancer	2C73	Phase 3	[4]
MK-8109	DM84LO5	Ovarian cancer	2C73	Phase 3	[5]
Farletuzumab	DMFLWX1	Non-small-cell lung cancer	2C25.Y	Phase 3	[6]
EC-145	DM0KVJC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[7]
FolateImmune	DMB9ADM	Renal cell carcinoma	2C90	Phase 2	[8]
Talotrexin	DM1AB4L	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[9]
BMS-753493	DMDQO0S	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[10]
EC0489	DM8RD4T	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
IMGN-853	DMR8OG2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 761310.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	EP patent application no. 2822386, Folate receptor alpha binding ligands.
5	A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer. Drug Des Devel Ther. 2015; 9: 4989-4996.
6	Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer.Gynecol Oncol.2013 Jun;129(3):452-8.
7	Significance of Folate Receptor alpha and Thymidylate Synthase Protein Expression in Patients with Non-Small Cell Lung Cancer treated with Pemetrexed. J Thorac Oncol. 2013 January; 8(1): 19-30.
8	Responsiveness of the Effective Consumer Scale (EC-17). J Rheumatol. 2009 Sep;36(9):2087-91.
9	Cancer chemotherapy: targeting folic acid synthesis. Cancer Manag Res. 2010; 2: 293-301.
10	A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):321-31.
11	National Cancer Institute Drug Dictionary (drug id 638649).
12	Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. Bioconjug Chem. 2010 Jan;21(1):84-92.