Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5TR49)

• Drug Name: XMT-1191 Drug Info
• Synonyms: XMT-1191; GTPL6486

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 25227633
  TTD Drug ID: DM5TR49

Molecule-Related Drug Atlas

Drug(s) Targeting Methionine aminopeptidase 2 (METAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beloranib	DM71CK8	Solid tumour/cancer	2A00-2F9Z	Phase 3	[3]
D-Methionine	DMMKGBP	N. A.	N. A.	Phase 3	[4]
ZGN-1061	DM9KB7A	Type 2 diabetes	5A11	Phase 2	[5]
M8891	DMZ9NVP	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
SDX-7320	DMU0Q6L	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
PPI-2458	DMSAQBC	Autoimmune diabetes	5A10	Phase 1	[7]
TNP-470	DMT0QK8	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[8]
2-Methyl-2-Propanol	DMHM5GJ	Discovery agent	N.A.	Investigative	[4]
2-(phenylsulfonamido)-5-propylbenzoic acid	DMDGAHO	Discovery agent	N.A.	Investigative	[9]
5-p-Tolyl-1H-[1,2,3]triazole	DM2W0AD	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Methionine aminopeptidase 2 (METAP2)	TTZL0OI	MAP2_HUMAN	Inhibitor	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6486).
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1573).
• [3] 2011 Pipeline of Zafgen.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in overweight and obese individuals with type 2 diabetes: A randomized, placebo-controlled trial. Diabetes Obes Metab. 2020 Jul;22(7):1215-1219.
• [6] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [7] Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity. Drug Metab Dispos. 2013 Apr;41(4):814-26.
• [8] Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2. Cancer Res. 2003 Nov 15;63(22):7861-9.
• [9] Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7.
• [10] 4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo. J Med Chem. 2005 Sep 8;48(18):5644-7.