Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5ZTE4)

Drug Name

PRO-001 Drug Info

Synonyms

PRO-001, ProRetina; Proinsulin (recombinant human protein, retinitis pigmentosa), ProRetina

Indication

Disease Entry	ICD 11	Status	REF
Retinitis pigmentosa	9B70	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Insulin-degrading enzyme (IDE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bacitracin	DM5OHYE	Blepharoconjunctivitis		Approved	[3]
GNF-PF-4478	DMCDU8K	Discovery agent	N.A.	Investigative	[4]
quinoline 2	DM1QIPZ	Discovery agent	N.A.	Investigative	[5]
NTE-2	DM4DB0W	Discovery agent	N.A.	Investigative	[5]
NTE-1	DMFIE0U	Discovery agent	N.A.	Investigative	[5]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Insulin-degrading enzyme (IDE)	TT2EDHU	IDE_HUMAN	Modulator	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT02520583) The Effects of Probiotic Supplementation on Markers of Muscle Damage and Performance Following Exercise Induced Muscle Damage.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2371).
3	Brain insulin impairs amyloid-beta(1-40) clearance from the brain. J Neurosci. 2004 Oct 27;24(43):9632-7.
4	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
5	Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J Biol Chem. 2015 Aug 14;290(33):20044-59.