Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM68JNY)

Drug Name

PI1 Drug Info

Synonyms

CHEMBL1801361; GTPL5814; SCHEMBL2383164; BDBM50348617

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

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Drug(s) Targeting Neuropeptide S receptor (NPSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27788040-Compound-6	DMHX8OF	N. A.	N. A.	Patented	[3]
Oxazolo[3,4-a]pyrazine derivative 4	DM1B74D	N. A.	N. A.	Patented	[3]
Imidazo pyridine derivative 4	DM3YMHP	N. A.	N. A.	Patented	[3]
4,5,6,7-tetrahydrofuro[3,4-c]pyridine-1(3H)-one derivative 1	DMCISHW	N. A.	N. A.	Patented	[3]
Oxazolo[3,4-a]pyrazine derivative 2	DM28E0A	N. A.	N. A.	Patented	[3]
Imidazo pyridine derivative 6	DMG6W3O	N. A.	N. A.	Patented	[3]
4,5,6,7-tetrahydrofuro[3,4-c]pyridine-1(3H)-one derivative 3	DMFOBM9	N. A.	N. A.	Patented	[3]
PMID27788040-Compound-6b	DMD3U96	N. A.	N. A.	Patented	[3]
Indandione derivative 2	DMVR04K	N. A.	N. A.	Patented	[3]
4,5,6,7-tetrahydrofuro[3,4-c]pyridine-1(3H)-one derivative 4	DM6MCBU	N. A.	N. A.	Patented	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuropeptide S receptor (NPSR)	TTV1C0Z	NPSR1_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5814).
2	Tricyclic imidazole antagonists of the Neuropeptide S Receptor. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4704-8.
3	Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362.