Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM68K39)

Drug Name

ETIPREDNOL DICLOACETATE Drug Info

Synonyms

BNP-166; Cronaze (Ivax); Ethinase (Ivax); Etiprednol dicloacetate < USAN; Respicort (Ivax); (11beta,17alpha)-17-(2,2-Dichloroacetoxy)-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid ethyl ester

Indication

Disease Entry	ICD 11	Status	REF
Rhinitis	FA20	Phase 2	[1]

Cross-matching ID

PubChem CID: 9935073
ChEBI ID: CHEBI:135783
CAS Number: CAS 199331-40-3
TTD Drug ID: DM68K39

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[3]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[4]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[5]
Fluticasone	DMGCSVF	Allergic rhinitis	CA08.0	Approved	[6]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[4]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[4]
Deflazacort	DMV0RNS	Duchenne dystrophy	8C70	Approved	[4]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[7]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[8]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00035503) Multicenter Trial For Patients With Acute Crohn's Disease. U.S. National Institutes of Health.
2	Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate.Int J Inflam.2012;2012:789623.
3	Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol. 2009 May;37(5):559-72.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-Fas1pr autoimmune mice. Laryngoscope. 2000 Nov;110(11):1902-6.
6	Fluticasone furoate nasal spray in allergic rhinitis. Drugs Today (Barc). 2008 Apr;44(4):251-60.
7	Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. ArchBiochem Biophys. 1996 May 1;329(1):113-22.
8	PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide. Eur J Pharm Sci. 2009 Mar 2;36(4-5):565-71.
9	The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values. Steroids. 2007 Jun;72(6-7):600-8.