Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM68RPD)

Drug Name

L-valine Drug Info

Synonyms

L-valine; valine; 72-18-4; (S)-Valine; H-Val-OH; (S)-2-Amino-3-methylbutanoic acid; 2-Amino-3-methylbutyric acid; (2S)-2-amino-3-methylbutanoic acid; (S)-2-Amino-3-methylbutyric acid; L-alpha-Amino-beta-methylbutyric acid; Valinum [Latin]; Valina [Spanish]; Valine (VAN); Valine [USAN:INN]; Butanoic acid, 2-amino-3-methyl-; VALINE, L-; L(+)-alpha-Aminoisovaleric acid; (S)-alpha-Amino-beta-methylbutyric acid; Butanoic acid, 2-amino-3-methyl-, (S)-; 2-Amino-3-methylbutyric acid, (S)-; 2-Amino-3-methylbutanoic acid, (S)-; L-valin

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6287
ChEBI ID: CHEBI:16414
CAS Number: CAS 72-18-4
TTD Drug ID: DM68RPD
VARIDT Drug ID: DR00236
INTEDE Drug ID: DR0996

Molecule-Related Drug Atlas

Molecule Type:

DTP

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Transported By L-type amino acid transporter 3 (SLC43A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[2]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[2]
L-isoleucine	DM4B6H3	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Transported By L-type amino acid transporter 4 (SLC43A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[3]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[3]
L-isoleucine	DM4B6H3	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
L-type amino acid transporter 3 (SLC43A1)	DTBMSWG	LAT3_HUMAN	Substrate	[2]
L-type amino acid transporter 4 (SLC43A2)	DTK02I1	LAT4_HUMAN	Substrate	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytosolic branched aminotransferase (BCAT1)	DE9B45K	BCAT1_HUMAN	Substrate	[4]
Propionyl-CoA carboxylase beta (PCCB)	DESWQMH	PCCB_HUMAN	Substrate	[5]
Valyl-tRNA synthetase (VARS)	DEUPF5K	SYVC_HUMAN	Substrate	[6]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4794).
2	Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45.
3	Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542.
4	Purification, crystallization and preliminary X-ray crystallographic analysis of branched-chain aminotransferase from Deinococcus radiodurans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):492-4.
5	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6	A present-day aminoacyl-tRNA synthetase with ancestral editing properties. RNA. 2007 Jan;13(1):15-21.