Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6M8Y3)

Drug Name
2-tert-butyl-9H-carbazole Drug Info
Synonyms
2-TERT-BUTYL-9H-CARBAZOLE; 69386-36-3; CHEMBL1173703; 2-(tert-Butyl)-9H-carbazole; 2-Tert-butylcarbazole; SCHEMBL10312973; CTK2F2146; DTXSID90499227; MolPort-005-941-197; ZINC22003756; BDBM50322580; AKOS015967050
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
12462654
CAS Number
CAS 69386-36-3
TTD Drug ID
DM6M8Y3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Kinesin spindle messenger RNA (KIF11 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ALN-VSP DM89DHO Liver cancer 2C12 Phase 1 [2]
EMD-534085 DMQ6YAZ Haematological malignancy 2B33.Y Phase 1 [3]
N-[4'-(trifluoromethyl)-4-biphenylyl]thiourea DMPVKWG Discovery agent N.A. Investigative [4]
N-[3'-(trifluoromethyl)-4-biphenylyl]urea DM7OA4R Discovery agent N.A. Investigative [4]
4'-(trifluoromethyl)-4-biphenylsulfonamide DMLP67R Discovery agent N.A. Investigative [4]
N-(4'-chloro-4-biphenylyl)methanesulfonamide DM0ARP8 Discovery agent N.A. Investigative [4]
ISIS 183881 DMOU9EP Discovery agent N.A. Investigative [5]
ISIS 183911 DMTB350 Discovery agent N.A. Investigative [6]
4'-(trifluoromethyl)-4-biphenylyl carbamate DMT3BX9 Discovery agent N.A. Investigative [4]
ISIS 183910 DMMQ2L7 Discovery agent N.A. Investigative [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kinesin spindle messenger RNA (KIF11 mRNA) TTBGTCW KIF11_HUMAN Inhibitor [1]

References

1 Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8.
2 Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011).
3 The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5.
4 Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52.
5 US patent application no. 7,407,943, Antisense modulation of apolipoprotein B expression.
6 US patent application no. 7,163,927, Antisense modulation of kinesin-like 1 expression.