Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6OJI1)

Drug Name

DIAPLASININ Drug Info

Synonyms

Diaplasinin < USAN; PAI-749; 1-Benzyl-3-pentyl-2-[6-(1H-tetrazol-5-ylmethoxy)naphthalen-2-yl]-1H-indole

Indication

Disease Entry	ICD 11	Status	REF
Thrombosis	DB61-GB90	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Endothelial plasminogen activator inhibitor (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
THR-18	DMBO021	Asthma	CA23	Phase 2	[2]
XR-5118	DMIK72F	Solid tumour/cancer	2A00-2F9Z	Terminated	[3]
AR-HO29953XX	DM2PRHX	Discovery agent	N.A.	Investigative	[4]
Sideroxylonal C	DMSGNM1	Discovery agent	N.A.	Investigative	[5]
SIDEROXYLONAL B	DMDP7Y5	Discovery agent	N.A.	Investigative	[5]
SIDEROXYLONAL A	DMEIBTY	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endothelial plasminogen activator inhibitor (SERPINE1)	TTTO43N	PAI1_HUMAN	Inhibitor	[1]

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References

1	Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. J Thromb Haemost. 2010 Jun;8(6):1333-9.
2	THR-18, a 18-mer peptide derived from PAI-1, is neuroprotective and improves thrombolysis by tPA in rat stroke models. Neurol Res. 2011 Nov;33(9):983-90.
3	Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem. 2004 Jul 1;47(14):3491-4.
4	Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3514-8.
5	Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens. J Nat Prod. 1999 Feb;62(2):324-6.