Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6PI5B)

Drug Name
M3258 Drug Info
Synonyms LMP7-IN-1; 2285330-15-4; NSC818432; NSC-818432; HY-111790; CS-0091883; ((R)-2-(Benzofuran-3-yl)-1-((1S,2R,4R)-7-oxabicyclo[2.2.1]heptane-2-carboxamido)ethyl)boronic acid
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Phase 1 [1]
Cross-matching ID
PubChem CID
138319683
TTD Drug ID
DM6PI5B

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Proteasome beta-8 (PS beta-8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Peptide analog 21 DMJDFS1 N. A. N. A. Patented [3]
Peptide analog 23 DMDU21R N. A. N. A. Patented [3]
Peptide analog 41 DM96KXE N. A. N. A. Patented [3]
PMID29865878-Compound-53 DM6JV1W N. A. N. A. Patented [3]
PMID29865878-Compound-55 DMY52ZB N. A. N. A. Patented [3]
PMID29865878-Compound-46 DMP3MXK N. A. N. A. Patented [3]
PMID29865878-Compound-48 DMVQTR2 N. A. N. A. Patented [3]
PMID29865878-Compound-51 DM0LXT2 N. A. N. A. Patented [3]
PMID29865878-Compound-49 DMK0GTV N. A. N. A. Patented [3]
Peptide analog 27 DML4XJ2 N. A. N. A. Patented [3]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proteasome beta-8 (PS beta-8) TTEAD9J PSB8_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT04075721) First in Human Dose Escalation of M3258 as a Single Agent and Expansion Study of M3258 in Combination With Dexamethasone. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of EMD Serono.
3 A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540.