Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6R4DO)

Drug Name

GC-1008 Drug Info

Synonyms

TGF-beta; TGF-Beta; Tgfbeta; TGF beta; Milk growth factor; Transforming Growth Factor beta; Platelet Transforming Growth Factor; Bone-Derived Transforming Growth Factor; TGF-beta; D016212000; 122304-04-5

Indication

Disease Entry	ICD 11	Status	REF
Idiopathic pulmonary fibrosis	CB03.4	Phase 1	[1]
Pleural disease	CB27	Investigative	[2]

Cross-matching ID

PubChem CID: 56842206
CAS Number: CAS 122304-04-5
TTD Drug ID: DM6R4DO

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TGF-beta receptor (TGFBR)	TT5BDCY	NOUNIPROTAC	Modulator	[3]

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References

1	Current and emerging drugs for idiopathic pulmonary fibrosis. Expert Opin Emerg Drugs. 2007 Nov;12(4):627-46.
2	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3	Phase I study of GC1008 (fresolimumab): a human anti-transforming growth factor-beta (TGF) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma.PLoS One.2014 Mar 11;9(3):e90353.