Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6RUKX)

Drug Name

BVT.2733 Drug Info

Synonyms

CHEMBL553071; AC1OCFOV; 376641-65-5; SCHEMBL5692696; MolPort-042-665-756; 3-chloro-2-methyl-N-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1,3-thiazol-2-yl]benzenesulfonamide hydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Lupus	4A40	Phase 3	[1]
Systemic lupus erythematosus	4A40.0	Phase 3	[1]
Myasthenia gravis	8C6Y	Phase 2	[1]
Non-insulin dependent diabetes	5A11	Investigative	[2]

Cross-matching ID

PubChem CID: 6918651
CAS Number: CAS 376640-41-4
TTD Drug ID: DM6RUKX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GLYCYRRHIZIN	DM8M2N3	Influenza virus infection	1E30-1E32	Phase 3	[3]
INCB13739	DMLQ3PO	Type-2 diabetes	5A11	Phase 2a	[4]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[5]
JTT-654	DM50M2R	Type-2 diabetes	5A11	Phase 2	[6]
RG-4929	DMT4QRD	Metabolic disorder	5C50-5D2Z	Phase 2	[6]
BMS-770767	DMTVGY7	Hypercholesterolaemia	5C80.0	Phase 2	[6]
UE-2343	DMIERPK	Alzheimer disease	8A20	Phase 2	[7]
AZD-4017	DML9M5S	Ocular hypertension	9C61.01	Phase 2	[6]
Xanamem	DM580GT	Alzheimer disease	8A20	Phase 1/2	[8]
BMS-816336	DM2WMJ7	Lipid metabolism disorder	5C52.Z	Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[2]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology. 2003 Nov;144(11):4755-62.
3	Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. Bioorg Med Chem. 2009 Aug 1;17(15):5722-32.
4	Incyte's Selective Oral Inhibitor Of 11beta-HSD1 Demonstrates Improvements In Insulin Sensitivity And Lowers Cholesterol Levels In Type 2 Diabetics. Incyte. 2008.
5	11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.
6	New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131).
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8	Selection and early clinical evaluation of the brain-penetrant 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor UE2343 (Xanamem?). Br J Pharmacol. 2017 Mar;174(5):396-408.
9	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027626)