Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6Y3AN)

Drug Name

Micafungin Drug Info

Synonyms

Mycamine; FK463; FK-463; Mycamine (TN); Mycamine(TM)

Indication

Disease Entry	ICD 11	Status	REF
Aspergillosis	1F20	Approved	[1]
Candidiasis	1F23	Approved	[2]
Invasive aspergillosis	1F20.0	Approved	[1]
Invasive candidiasis	1F23	Approved	[1]
Candidemia	1F23.3Y	Investigative	[1]
Esophageal candidiasis		Investigative	[1]

Therapeutic Class

Antifungal Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Fungal 1,3-beta-glucan synthase (Fung GSC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caspofungin	DMGQIPT	Candidiasis	1F23	Approved	[5]
Rezafungin	DMQ4CSX	Candidiasis	1F23	Approved	[6]
Ibrexafungerp	DMK1IPV	Vulvovaginal Candidiasis	1F23.10	Approved	[7]
Anidulafungin	DM8QM5U	Aspergillosis	1F20	Approved	[8]
L-733560	DMYZPJU	Aspergillosis	1F20	Terminated	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fungal 1,3-beta-glucan synthase (Fung GSC2)	TT0SFXH	FKS2_YEAST	Modulator	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Arylsulfatase A (ARSA)^{Main DME}	DEJ6FSR	ARSA_HUMAN	Substrate	[4]

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References

1	Micafungin FDA Label
2	Echinocandins: pharmacokinetic and therapeutic issues. Curr Med Res Opin. 2009 Jul;25(7):1741-50.
3	An immunomodulatory activity of micafungin in preclinical aspergillosis. J Antimicrob Chemother. 2014 Apr;69(4):1065-74.
4	The echinocandin micafungin: a review of the pharmacology, spectrum of activity, clinical efficacy and safety. Expert Opin Pharmacother. 2007 Jun;8(8):1155-66.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	Antifungal drugs: What brings the future?. Med Mycol. 2019 Jun 1;57(Supplement_3):S328-S343.
7	Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model. Antimicrob Agents Chemother. 2015 Feb;59(2):1265-72.
8	2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
9	Discovery of Novel Antifungal (1,3)--d-Glucan Synthase Inhibitors