Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM74HGJ)

• Drug Name: acetyl-L-carnitine Drug Info
• Synonyms: UNII-521T0J13MA; acetyl-d-carnitine; 521T0J13MA; (3S)-3-acetoxy-4-(trimethylammonio)butyrate; 1-Propanaminium, 2-(acetyloxy)-3-carboxy-N,N,N-trimethyl-, inner salt, (2S)-; 4398-79-2; O-acetylcarnitine; CAR(2:0); Acylcarnitine C2:0; O-acetyl-D-carnitine; AC1L2BM0; Acetylcarnitine, (R)-Isomer; SCHEMBL677128; C9H18NO4; GTPL4520; CHEBI:86045; DTXSID90196007; 1-Propanaminium, 2-(acetyloxy)-3-carboxy-N,N,N-trimethyl-, hydroxide, inner salt, (R)-; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, acetate, L-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 7045767
  ChEBI ID: CHEBI:57589
  CAS Number: CAS 3040-38-8
  TTD Drug ID: DM74HGJ
  VARIDT Drug ID: DR00150

Molecule-Related Drug Atlas

Drug(s) Transported By Organic cation/carnitine transporter 2 (SLC22A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[3]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[2]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[4]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[5]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[6]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[7]
Tiotropium	DMFDC0Q	Chronic obstructive pulmonary disease	CA22	Approved	[8]
Ipratropium	DMFQ320	Obstructive lung disease	CA22.Z	Approved	[8]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[9]
Acetylcarnitine	DM4UE3K	Chronic fatigue syndrome	8E49	Phase 4	[10]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation/carnitine transporter 2 (SLC22A5)	DT3HUVD	S22A5_HUMAN	Substrate	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4520).
• [2] Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84.
• [3] Genetic variations of the SLC22A5 gene in the Chinese and Indian populations of Singapore. Drug Metab Pharmacokinet. 2010;25(1):112-9.
• [4] Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
• [5] Colistin is substrate of the carnitine/organic cation transporter 2 (OCTN2, SLC22A5). Drug Metab Dispos. 2017 Dec;45(12):1240-1244.
• [6] Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. J Pharmacol Exp Ther. 2005 Jan;312(1):192-8.
• [7] Mutations affecting GABAergic signaling in seizures and epilepsy. Pflugers Arch. 2010 Jul;460(2):505-23.
• [8] Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95.
• [9] Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice. Biopharm Drug Dispos. 2009 Dec;30(9):495-507.
• [10] Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2. Arch Biochem Biophys. 2006 Aug 1;452(1):29-37.