Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM78NOM)

Drug Name

furin inhibitor peptide Drug Info

Synonyms

CHEMBL502642; furin inhibitor peptide; GTPL8668

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Patented Agent(s)

Preclinical Drug(s)

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Drug(s) Targeting Proprotein convertase subtilisin/kexin type 7 (PCSK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
peptide 18	DMIDP1R	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Dibasic-processing enzyme (Furin)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9266828, E	DMYUL2X	N. A.	N. A.	Patented	[3]
US9266828, C	DMQEL1W	N. A.	N. A.	Patented	[3]
US9266828, B	DMYUDCE	N. A.	N. A.	Patented	[3]
DecRVKRCMK	DMAUILH	Coronavirus infection	1D92	Preclinical	[4]
peptide 18	DMIDP1R	Discovery agent	N.A.	Investigative	[2]
MI-1148	DMCN91V	Discovery agent	N.A.	Investigative	[5]
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⏷ Show the Full List of 6 Drug(s)

Drug(s) Targeting Proprotein convertase subtilisin/kexin type 6 (PCSK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
peptide 18	DMIDP1R	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dibasic-processing enzyme (Furin)	TTH9WF6	FURIN_HUMAN	Inhibitor	[1]
Proprotein convertase subtilisin/kexin type 4 (PCSK4)	TTK3VYC	PCSK4_HUMAN	Inhibitor	[1]
Proprotein convertase subtilisin/kexin type 5 (PCSK5)	TTPFWHU	PCSK5_HUMAN	Inhibitor	[1]
Proprotein convertase subtilisin/kexin type 6 (PCSK6)	TT75LN9	PCSK6_HUMAN	Inhibitor	[1]
Proprotein convertase subtilisin/kexin type 7 (PCSK7)	TTD30LY	PCSK7_HUMAN	Inhibitor	[1]

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References

1	Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53.
2	Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109.
3	Inhibitors of Furin and other pro-protein convertases. US9266828.
4	Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. Viruses. 2019 Oct 31;11(11):1011.
5	Novel Furin Inhibitors with Potent Anti-infectious Activity. ChemMedChem. 2015 Jul;10(7):1218-31.