Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7C68W)

Drug Name

AST-008 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Toll-like receptor 9 (TLR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cadi-05	DMPTCYB	Prostate cancer	2C82.0	Phase 3	[2]
SD-101	DMAMTGI	Hepatitis C virus infection	1E51.1	Phase 3	[3]
MGN-1703	DMCJRL1	Colorectal cancer	2B91.Z	Phase 3	[4]
IMO-2125	DM735FA	Melanoma	2C30	Phase 3	[5]
Tilsotolimod	DMGYK2N	Melanoma	2C30	Phase 3	[6]
MIS-416	DM7K4YR	Autoimmune diabetes	5A10	Phase 2	[7]
IMO-3100	DMM549D	Psoriasis vulgaris	EA90	Phase 2	[8]
BL-7040	DMSBPJI	Inflammatory bowel disease	DD72	Phase 2	[9]
CYT003	DM4LJH8	Asthma	CA23	Phase 2	[10]
CpG-10101	DM6MUCX	Hepatitis C virus infection	1E51.1	Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.
3	Novel drugs targeting Toll-like receptors for antiviral therapy. Future Virol. 2014 September; 9(9): 811-829.
4	Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial. J Cancer Res Clin Oncol. 2014 Sep;140(9):1615-24.
5	Clinical pipeline report, company report or official report of Idera Pharmaceuticals (2011).
6	Tilsotolimod with ipilimumab drives tumor responses in anti-PD-1 refractory melanoma. Cancer Discov. 2021 Mar 11;candisc.1546.2020.
7	DOI: 10.1371/journal.pone.0087712
8	Company report (Iderapharma)
9	Gut feeling: MicroRNA discriminators of the intestinal TLR9-cholinergic links. Int Immunopharmacol. 2015 Nov;29(1):8-14.
10	CYT003, a TLR9 agonist, in persistent allergic asthma - a randomized placebo-controlled Phase 2b study. Allergy. 2015 Sep;70(9):1160-8.
11	Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10101 (ACTILON), an investigational synthetic toll-like receptor 9 agonist. Antivir Ther. 2007;12(5):741-51.