Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7JRHB)

Drug Name

PMID21596927C101 Drug Info

Synonyms

cmpd101; Takeda compound 101; 865608-11-3; 3pvu; QRW; GTPL8437; MolPort-039-338-070; ZINC38226912; AKOS027470239

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Beta-adrenergic receptor kinase 1 (ADRBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9493490, E	DMFCIGE	N. A.	N. A.	Patented	[2]
US9493490, D	DMUVC25	N. A.	N. A.	Patented	[2]
US9493490, C	DMC1YR5	N. A.	N. A.	Patented	[2]
BDBM50173306	DMSTD28	N. A.	N. A.	Patented	[3]
US9493490, L	DMJDTSN	N. A.	N. A.	Patented	[2]
PMID24210504C1o	DM4LEUT	Discovery agent	N.A.	Investigative	[4]
BetaARKct	DMN7DJ5	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Beta-adrenergic receptor kinase 1 (ADRBK1)	TTAZ3MN	ARBK1_HUMAN	Inhibitor	[1]
Beta-adrenergic receptor kinase 2 (ADRBK2)	TT5A4DX	ARBK2_HUMAN	Inhibitor	[1]

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References

1	Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors. Mol Pharmacol. 2011 Aug;80(2):294-303.
2	Boron-containing small molecules. US9493490.
3	G protein-coupled receptor kinase 2 inhibitors and methods for use of the same. US10023564.
4	Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6711-6.
5	Gene-mediated inhibition of the b-adrenergic receptor kinase: a new therapeutic strategy for heart failure. Minerva Cardioangiol. 2001 Dec;49(6):389-94.