Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7SA9J)

Drug Name

IR-103 Drug Info

Synonyms

HIV vaccine + Amplivax, IRC; HIV vaccine + Amplivax, Immune Response Corp; HIV vaccine + HYB-2055, IRC; HIV vaccine + HYB-2055, Immune Response Corp; Vaccine (HIV) + Amplivax, IRC; Vaccine (HIV) + Amplivax, Immune Response Corp; Vaccine (HIV) + HYB-2055, IRC; Vaccine (HIV) + HYB-2055, Immune Response Corp

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Discontinued in Phase 3	[1]

Cross-matching ID

TTD Drug ID: DM7SA9J

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Toll-like receptor 9 (TLR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cadi-05	DMPTCYB	Prostate cancer	2C82.0	Phase 3	[3]
SD-101	DMAMTGI	Hepatitis C virus infection	1E51.1	Phase 3	[4]
MGN-1703	DMCJRL1	Colorectal cancer	2B91.Z	Phase 3	[5]
IMO-2125	DM735FA	Melanoma	2C30	Phase 3	[6]
Tilsotolimod	DMGYK2N	Melanoma	2C30	Phase 3	[7]
MIS-416	DM7K4YR	Autoimmune diabetes	5A10	Phase 2	[8]
IMO-3100	DMM549D	Psoriasis vulgaris	EA90	Phase 2	[9]
BL-7040	DMSBPJI	Inflammatory bowel disease	DD72	Phase 2	[10]
CYT003	DM4LJH8	Asthma	CA23	Phase 2	[11]
CpG-10101	DM6MUCX	Hepatitis C virus infection	1E51.1	Phase 2	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Toll-like receptor 9 (TLR9)	TTSHG0T	TLR9_HUMAN	Not Available	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019204)
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1759).
3	Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.
4	Novel drugs targeting Toll-like receptors for antiviral therapy. Future Virol. 2014 September; 9(9): 811-829.
5	Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial. J Cancer Res Clin Oncol. 2014 Sep;140(9):1615-24.
6	Clinical pipeline report, company report or official report of Idera Pharmaceuticals (2011).
7	Tilsotolimod with ipilimumab drives tumor responses in anti-PD-1 refractory melanoma. Cancer Discov. 2021 Mar 11;candisc.1546.2020.
8	DOI: 10.1371/journal.pone.0087712
9	Company report (Iderapharma)
10	Gut feeling: MicroRNA discriminators of the intestinal TLR9-cholinergic links. Int Immunopharmacol. 2015 Nov;29(1):8-14.
11	CYT003, a TLR9 agonist, in persistent allergic asthma - a randomized placebo-controlled Phase 2b study. Allergy. 2015 Sep;70(9):1160-8.
12	Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10101 (ACTILON), an investigational synthetic toll-like receptor 9 agonist. Antivir Ther. 2007;12(5):741-51.