Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7UJ1I)

Drug Name

FX-107 Drug Info

Synonyms

FX-06; FX-06); FX-06HS; FX-06MRI; FX-108; FX-201; IK-600X program; Bbeta(15-42); FX-06 analogs (transplantation), Fibrex Medical; FX-06 analogs (transplantation), Ikaria; Peptide leukocyte migration inhibitor (reperfusion injury/hemorrhagic shock), Ikaria; Peptide leukocyte migration inhibitor (reperfusion injury/hemorrhagic shock), FIBREX Medical R&D; FX-06 analogs (sepsis, septic shock, Dengue), Fibrex Medical

Indication

Disease Entry	ICD 11	Status	REF
Dengue fever	1D2Z	Preclinical	[1]

Cross-matching ID

TTD Drug ID: DM7UJ1I

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Fibrin (FG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beriplast-P	DMEBY2D	Wound healing	EL8Y	Approved	[3]
Baquting	DME1DJX	Bleeding disorder	GA20-GA21	Approved	[4]
Fibrinolysin	DM9Q8SO	Wound healing	EL8Y	Approved	[5]
TachoComb	DM6S0HB	Wound healing	EL8Y	Approved	[6]
Adhexil	DMFIP35	Injury	NA00-ND5Z	Phase 3	[7]
Alfimeprase	DMVHRL8	Peripheral vascular disease	BD4Z	Phase 3	[8]
Recombinant batroxobin	DMURX4B	Blood forming organ disorder	JB64.1	Phase 2	[9]
KUR-212	DMB4HCY	Wound healing	EL8Y	Phase 2	[10]
Plasmin	DMOB1EM	Occlusive disease	BD4Z	Phase 2	[11]
KUR-211	DM2N0Z3	Ulcer	CA02-CB40	Phase 2	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fibrin (FG)	TTWODQF	FIBA_HUMAN; FIBB_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023709)
2	FX-06, a fibrin-derived Bbeta15-42 peptide for the potential treatment of reperfusion injury following myocardial infarction. Curr Opin Investig Drugs. 2009 Sep;10(9):997-1003.
3	Wound healing and degradation of the fibrin sealant Beriplast P following partial liver resection in rabbits. Wound Repair Regen. 2005 May-Jun;13(3):318-23.
4	Baquting, enable our sales and marketing team to effectively promote our principal products and help to stimulate the sales of our other pharmaceuticals.
5	FIBRINOLYSIN, FIBRIN AND HYALINE MEMBRANES. Pediatrics. 1963 Nov;32:940-2.
6	Pancreaticojejunostomy using a fibrin adhesive sealant (TachoComb) for the prevention of pancreatic fistula after pancreaticoduodenectomy. Hepatogastroenterology. 2011 Jan-Feb;58(105):187-91.
7	Evaluation of a fibrin preparation containing tranexamic acid (Adhexil) in a rabbit uterine horn model of adhesions with and without bleeding and in a model with two surgical loci. Fertil Steril. 2010 Mar 1;93(4):1045-51.
8	Disulfide structure of alfimeprase: A recombinant analog of fibrolase. Protein Sci. 2001 June; 10(6): 1264-1267.
9	Functional characterization of recombinant batroxobin, a snake venom thrombin-like enzyme, expressed from Pichia pastoris. FEBS Lett. 2004 Jul 30;571(1-3):67-73.
10	Clinical pipeline report, company report or official report of Kuros.
11	ClinicalTrials.gov (NCT01014975) A Safety and Dose Finding Study of Plasmin (Human) Administered Into the Middle Cerebral Artery of Stroke Patients. U.S. National Institutes of Health.
12	Clinical pipeline report, company report or official report of Kuros.