Details of the Drug-Related molecule(s) Interaction Atlas

PMID30247903-Compound-General structure24 Drug Info

PMID30247903Compound24

Cross-matching ID

TTD Drug ID

DM8CPZB

General Information of Drug (ID: DM8CPZB)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Programmed cell death protein 1 (PD-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nivolumab	DMAB9QE	Melanoma	2C30	Approved	[2]
Tislelizumab	DMGVUO5	Hodgkin lymphoma	2B30	Approved	[3]
MK-3475	DMBYNW0	Melanoma	2C30	Approved	[2]
Pembrolizumab	DMFQEA6	Melanoma	2C30	Approved	[1]
Cemiplimab	DMKMJHE	Cutaneous squamous cell carcinoma	2C30	Approved	[4]
Retifanlimab	DMRKTCP	Neuroendocrine cancer	2B72.1	Approved	[5]
Sintilimab	DMGWR0C	Hodgkin lymphoma	2B30	Approved	[6]
Dostarlimab	DM78NWP	Endometrial cancer	2C76	Approved	[7]
Toripalimab	DMSGA6Z	Demodex blepharitis	1G07	Approved in China	[8]
PDR001	DM53J6B	Melanoma	2C30	Phase 3	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Programmed cell death protein 1 (PD-1)	TTNBFWK	PDCD1_HUMAN	Inhibitor	[1]

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References

1	Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
2	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
3	Tislelizumab: an investigational anti-PD-1 antibody for the treatment of advanced non-small cell lung cancer (NSCLC). Expert Opin Investig Drugs. 2020 Dec;29(12):1355-1364.
4	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Sintilimab: First Global Approval. Drugs. 2019 Feb;79(3):341-346.
7	Dostarlimab in the treatment of recurrent or primary advanced endometrial cancer. Future Oncol. 2021 Mar;17(8):877-892.
8	Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China. Front Immunol. 2022 Jan 12;12:730666.
9	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)