Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8DYJQ)

Drug Name

SHP656 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Glioblastoma of brain	2A00.00	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cryptochrome circadian clock 1 (CRY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Ethoxypropanoic acid	DMAM4FE	Breast cancer	2C60-2C65	Preclinical	[2]
KL001	DMHX1LA	Glioblastoma of brain	2A00.00	Preclinical	[3]
TH301	DM4BDGW	Glioblastoma of brain	2A00.00	Preclinical	[1]
KL044	DMG3FDE	Discovery agent	N.A.	Investigative	[4]
------------------------------------------------------------------------------------

Drug(s) Targeting Cryptochrome-2 (CRY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Ethoxypropanoic acid	DMAM4FE	Breast cancer	2C60-2C65	Preclinical	[2]
KL001	DMHX1LA	Glioblastoma of brain	2A00.00	Preclinical	[3]
TH301	DM4BDGW	Glioblastoma of brain	2A00.00	Preclinical	[1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cryptochrome circadian clock 1 (CRY1)	TT5MLZR	CRY1_HUMAN	Modulator	[1]
Cryptochrome-2 (CRY2)	TTAO58M	CRY2_HUMAN	Modulator	[1]

------------------------------------------------------------------------------------

References

1	Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
2	The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55.
3	Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7.
4	Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97.