Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8FD3Z)

Drug Name

HG-9-91-01 Drug Info

Synonyms

HY-15776

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Salt-inducible kinase 1 (SIK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID24900538C2c	DM5PATM	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Salt-inducible kinase 2 (SIK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GRN-300	DMISPYI	Ovarian cancer	2C73	Phase 1	[3]
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Drug(s) Targeting SIK family kinase 3 (SIK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GRN-300	DMISPYI	Ovarian cancer	2C73	Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Salt-inducible kinase 1 (SIK1)	TT1H6LC	SIK1_HUMAN	Inhibitor	[1]
Salt-inducible kinase 2 (SIK2)	TTCUGZR	SIK2_HUMAN	Inhibitor	[1]
SIK family kinase 3 (SIK3)	TTW6L4V	SIK3_HUMAN	Inhibitor	[1]

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References

1	Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91.
2	Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9.
3	Clinical pipeline report, company report or official report of Green3Bio