Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8FTJN)

Drug Name

Glycyl-L-Alpha-Amino-Epsilon-Pimelyl-D-Alanine Drug Info

Synonyms

GLYCYL-L-ALPHA-AMINO-EPSILON-PIMELYL-D-ALANINE; REY; AC1L9JH9; DB03927; (2S)-2-[(2-aminoacetyl)amino]-7-[[(2R)-1-hydroxy-1-oxopropan-2-yl]amino]-7-oxoheptanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 446307
TTD Drug ID: DM8FTJN

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial DD-carboxypeptidase (Bact vanYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefalotin	DMVYSLE	Bacteremia	1A73	Approved	[2]
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[3]
Cephalosporin	DM79XDW	Bacterial infection	1A00-1C4Z	Approved	[4]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[5]
TD-1792	DMGKBZH	Skin infection	1F28-1G0Z	Phase 3	[6]
Phenyl Boronic acid	DMFZH49	Discovery agent	N.A.	Investigative	[7]
Cephalosporin C	DMYW3ZG	Discovery agent	N.A.	Investigative	[8]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[1]
D-Alanine	DMVIDQL	Discovery agent	N.A.	Investigative	[1]
3-boronobenzoic acid	DMRCJW0	Discovery agent	N.A.	Investigative	[7]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial DD-carboxypeptidase (Bact vanYB)	TTLP6GN	VANY_ENTFA	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases. Biochemistry. 1995 Jul 25;34(29):9532-40.
3	Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
4	A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1427-31.
5	Extended-spectrum cephalosporinases: structure, detection and epidemiology. Future Microbiol. 2007 Jun;2:297-307.
6	How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
7	Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. J Med Chem. 2009 Oct 8;52(19):6097-106.
8	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.